Antidepressant Discontinuation Syndrome – Its signs and symptoms

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What is Antidepressants Discontinuation Syndrome?

Antidepressants discontinuation syndrome refers to the interruption of the medical course of an antidepressant medication. It is also previously referred to as ‘withdrawal syndrome’.


Symptoms of antidepressants syndrome may include

  • Symptoms of flu
  • Insomnia, loss of sleep
  • Vomiting or indigestion of food
  • Head spinning or imbalance
  • Sensory disturbances
  • Anxiety
  • Hyper Arousal

The symptoms of this condition can vary from patient to patient, but these are the most common ones noted.


Every case takes a different time duration for symptoms to stop. If a drug is stopped abruptly the symptoms might take 3 to 4 days to kick in. And are usually subsided after 2 to 3 weeks.

It is possible, in rare cases, to suffer from the symptoms over the course of a year or two.

The role of cells and molecules in the antidepressants syndrome is being studied by biotech consulting firms working with pharmaceutical companies.

The study forwarded by the researchers at the University of Illinois Chicago (U I C) shows the protracted suppression of signal of membrane lipid raft that they usually refer to as “constellation of symptoms known as antidepressant discontinuation syndrome.”

Researchers hope to uncover more techniques for reducing withdrawal symptoms as well as developing new antidepressants when their research is complete.

Major depressive disorder

Happiness and sadness are the emotions that are a part of our lives. But their emotions are temporary or short-lived.

If someone experiences prolonged or intense feelings of sadness which is persistent and doesn’t leave they may have a mood disorder such as major depressive disorder (MDD).

Major depressive disorder also impacts your daily life significantly. From your work to your mood and behavior as well as your physical functions. That’s why it’s also called clinical disorder.

Top life science consulting firms never cease to provide aid in this matter. Scientists concluded that MDD is one of the major causes of disabilities worldwide. According to WHO approximately one in six people suffers depression. And there is no one-way cure for depression known to be effective for everyone.

60 percent of patients respond to initiating therapy. And the rest leave after two or three attempts at medicine. There is a long duration for the effect of medicine to occur and longer gaps of discontinuation symptoms. Therefore, many people drop out in the middle of therapy. Whereas, some people may continue their drugs for longer periods of time. For both the cases antidepressants discontinuation syndrome is inevitable and all share the symptoms mentioned above.


Clare Louise

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